Non-randomized mtDNA damage after ionizing radiation via charge transport

Non-randomized mtDNA damage after ionizing radiation via charge transport

Although it is well known that there are mutation hot spots in mtDNA, whether there are damage hot spots remain elusive. In this study, the regional DNA damage of mitochondrial genome after ionizing radiation was determined by real-time quantitative PCR. The mtDNA damage level was found to be dose-dependent and regional unequal. The control region was the most susceptible region to oxidative da...

Radiation Effects and Damage 1. Ionizing Radiations

The detrimental consequences of radiation are referred to as radiation damage. To understand the effects of radiation, one must first be familiar with the radiations and their interaction mechanisms. Further, the fundamental characteristics of the material(s) being irradiated must also be understood. A brief summary of the characteristics of radiation is first presented below. This is followed ...

ICNIRP Statement GENERAL APPROACH TO PROTECTION AGAINST NON-IONIZING RADIATION International Commission on Non-Ionizing Radiation Protection* ICNIRP Statement GENERAL APPROACH TO PROTECTION AGAINST NON-IONIZING RADIATION

ICNIRP Statement GENERAL APPROACH TO PROTECTION AGAINST NON-IONIZING RADIATION International Commission on Non-Ionizing Radiation Protection* ICNIRP Statement GENERAL APPROACH TO PROTECTION AGAINST NON-IONIZING RADIATION

Effect of Exposure to Ionizing Radiation on Biomarker of Oxidative Damage of DNA

Introduction: one of the most important complications of exposure to ionizing radiation is emergence of cancer tumors, which happens as a result of oxidative DNA.  Therefore, the present study was conducted, aimed to measuring 8-DIHYDROxy- 2’- DEOXYGUANOSINE (8-OHdG) level in radiographers’ urine as oxidative damage biomarker, as well as comparing this biomarker with cumulative effective doses....